Tendinopathy: Debate on concepts and pathogenesis / 中国组织工程研究

BACKGROUND: Tendinopathy is a hotspot in the fields of sports medicine and rehabilitation, but there have been many controversies about the concept, mechanism and pathological stages of tendinopathy for a long. OBJECTIVE: To systematically review and summarize the related concepts of tendinopathy, the role of inflammation in the occurrence of tendinopathy and the pathological mechanism of tendinopathy. METHODS: CNKI, VIP, CBM, WanFang, PubMed and Embase databases were searched. From the aspects of tendinopathy, enthesis, inflammation and pathological mechanism, some related research results since 1990 were retrieved and summarized. RESULTS AND CONCLUSION: The results show that the debate on the concept of tendinopathy is based on the understanding of its pathological mechanism, and the understanding of the pathological mechanism of tendinopathy will continue to be improved with the emergence of more high-quality researches. The research on the relationship between tendinopathy and inflammation, the relationship between tendinopathy and load patterns, and the mechanical characteristics of enthesis will be a future focus.

Non-functional paraganglioma of urinary bladder managed by transurethral resection

ABSTRACT Purpose As a rare bladder tumor, paraganglioma of the urinary bladder (PUB) is frequently misdiagnosed as bladder cancer, particularly for the non-functional type. To date, transurethral resection remains a controversial treatment for non-functional PUB. This study aimed to identify the clinical features, pathological characteristics, prognosis, and safe/effective treatment of non-functional PUB using transurethral resection of the bladder tumor (TURBT). Materials and Methods The clinical records, radiological data, pathological characteristics and follow-up times were retrospectively reviewed in 10 patients with clinically and pathologically proven non-functional PUB in our hospital from January 2008 to November 2016. All patients underwent TURBT treatment. Results The incidence of non-functional PUB in patients with bladder cancer was 0.17%. The mean age at diagnosis was 44.5 ± 13.6 years (range, 29-70 years), and the patient population had a female: male ratio of 3: 2. No patients had excess catecholamine (CA) whilst four patients had painless hematuria. All neoplasms were completely resected via TURBT. The majority of samples were positive for immunohistochemical markers including chromogranin A (CgA) and Synaptophysin (Syn), but were negative for cytokeratins (CKs). Only a single recurrence was observed from the mean follow-up period of 36.4 ± 24.8 months. Conclusion Complete TURBT is a safe and efficient treatment that serves both diagnostic and therapeutic purposes. Histopathological and immunohistochemistry examinations are mandatory for diagnostic confirmation. Long-term follow-up is recommended for patients with non-functional PUB.

Self-health management ability of college students of Zhuang nationality in underdeveloped areas and assoliated factors / 中国学校卫生

Objective@#To understand the self-health management ability of college students of Zhuang nationality in the economically underdeveloped areas of Guangxi and assoliated factors, and to provide support for improving the health of college students in economically underdeveloped areas.@*Methods@#Five colleges and universities were selected in the economically underdeveloped areas of Guangxi, and 1 042 college students of Zhuang nationality were randomly selected to conduct self-health management ability surveys, and the influencing factors affecting self-health management ability were analyzed.@*Results@#The self-health management ability of Zhuang college students in the economically underdeveloped areas of Guangxi scored (3.63±0.59) points. The scores of boys’ self-health management behaviors were higher than those of girls, which was statistically significant (t=2.92, P<0.01). There was a statistically significant difference in the total scores of cognitive and self-health management among students of different grades (F=8.03, 3.04, P<0.01). The dimensions and total scores of self-health management of medical students were higher than those of other majors, and there was statistical significance (P<0.01). The scores of behavior, environment and total scores of students with different self-assessment status were statistically significant (P<0.01). Regression analysis showed that professional, gender, and self-rated health were the main influencing factors of behavior and environment (P<0.01); gender, grade, and major were the main influencing factors of cognition (P<0.01); grade, professional, self-evaluation health were the main influencing factors of the total score of self-health management (P<0.01).@*Conclusion@#The Zhuang nationality students in the economically underdeveloped areas of Guangxi have higher self-health management ability, but their behaviors are not very good. They should be intervened and guided by different groups to improve the self-health management ability of Zhuang college students.

Chronic hepatitis virus infection in patients with multiple myeloma: clinical characteristics and outcomes

OBJECTIVES: Cytotoxic agents and steroids are used to treat lymphoid malignancies, but these compounds may exacerbate chronic viral hepatitis. For patients with multiple myeloma, the impact of preexisting hepatitis virus infection is unclear. The aim of this study is to explore the characteristics and outcomes of myeloma patients with chronic hepatitis virus infection. METHODS: From 2003 to 2008, 155 myeloma patients were examined to determine their chronic hepatitis virus infection statuses using serologic tests for the hepatitis B (HBV) and C viruses (HCV). Clinical parameters and outcome variables were retrieved via a medical chart review. RESULTS: The estimated prevalences of chronic HBV and HCV infections were 11.0 percent (n = 17) and 9.0 percent (n = 14), respectively. The characteristics of patients who were hepatitis virus carriers and those who were not were similar. However, carrier patients had a higher prevalence of conventional cytogenetic abnormalities (64.3 percent vs. 25.0 percent). The cumulative incidences of grade 3-4 elevation of the level of alanine transaminase, 30.0 percent vs. 12.0 percent, and hyperbilirubinemia, 20.0 percent vs. 1.6 percent, were higher in carriers as well. In a Kaplan-Meier analysis, carrier patients had worse overall survival (median: 16.0 vs. 42.4 months). The prognostic value of carrier status was not statistically significant in the multivariate analysis, but an age of more than 65 years old, the presence of cytogenetic abnormalities, a beta-2-microglobulin level of more than 3.5 mg/L, and a serum creatinine level of more than 2 mg/ dL were independent factors associated with poor prognosis. CONCLUSION: Myeloma patients with chronic hepatitis virus infections might be a distinct subgroup, and close monitoring of hepatic adverse events should be mandatory.